references in folk law to the cancer healing properties of the yew tree. The modern history of the drug taxol began in 1962 when Dr. A. Barclay, working for the U.S. collected bark from the Pacific Yew tree (Taxus brevifolia), pictured opposite, as part of a project aimed at the discovery of new anticancer agents. Interest in the Pacific Yew tree heightened considerably after the discovery of it's activity against a number of leukaemias and solid tumours in the breast, ovary, brain, and lung in humans. This sparked off an intense period of research aimed at isolating the chemical responsible for the yew tree's activity and concluded in 1967 with the isolation of taxol in minute quantities. The amount of taxol that can be extracted from the yew tree is very small. The sacrifice of one 100 year old tree would result in approximately only 350mg of taxol, just about enough for one single dose for a cancer patient. In 1971 Wall, Wani and coworkers at theeported the molecular structure of taxol (1) on the basis of X-ray crystallographic data.
1: taxol
